Pharmacokinetics and Metabolism in Drug Design (Methods and Principles in Medicinal Chemistry, Band 31) - copertina rigida, flessible

EAN (ISBN-13): 9783527313686
ISBN (ISBN-10): 3527313680
Copertina rigida
Anno di pubblicazione: 2006
Editore: Wiley-VCH Verlag GmbH & Co. KGaA
187 Pagine
Peso: 0,609 kg
Lingua: eng/Englisch

Libro nella banca dati dal 2007-05-30T15:46:56+02:00 (Rome)
Pagina di dettaglio ultima modifica in 2022-05-21T01:33:30+02:00 (Rome)
ISBN/EAN: 9783527313686

ISBN - Stili di scrittura alternativi:
3-527-31368-0, 978-3-527-31368-6
Stili di scrittura alternativi e concetti di ricerca simili:
Autore del libro : gerd folkers, raimund, hugo kubinyi, dennis smith, walker, han, van waterbeemd, don smith
Titolo del libro: drug metabolism, design methods, methods and principles medicinal chemistry, metabol, meta design, pharmacokinetics drugs

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Dati dell'editore

Autore: Dennis A. Smith; Han van de Waterbeemd; Don K. Walker
Titolo: Methods and Principles in Medicinal Chemistry; Pharmacokinetics and Metabolism in Drug Design
Editore: Wiley-VCH
187 Pagine
Anno di pubblicazione: 2006-02-20
Peso: 0,520 kg
Lingua: Inglese
125,00 € (DE)
Not available (reason unspecified)

BB; GB; Hardcover, Softcover / Chemie; Verstehen; Pharmakokinetik; Arzneimitteldesign

PHYSICOCHEMISTRY Partition and Distribution Coefficient as Measures of Lipophilicity Limitations on the Use of Octanol Further Understanding of log P Alternative Lipophilicity Scales Computational Approaches to Lipophilicity Membrane Systems to Study Drug Behaviour NEW: Dissolution and Solubility NEW: Ionisation (pKa) PHARMACOKINETICS Intravenous Administration: Volume of Distribution Intravenous Administration: Clearance Clearance and Half-Life Intravenous administration: Infusion Oral Administration Repeated Doses Development of the Unbound (Free) Drug Model Unbound Drug and Drug Action Unbound Drug Model and Barriers to Equilibrium Slow Offset Compounds Factors Governing Unbound Drug Concentration ABSORPTION The Absorption Process Dissolution Membrane Transfer Barriers to Membrane Transfer Models for Absorption Estimation Estimation of Absorption Potential Computational Approaches DISTRIBUTION Membrane Transfer Access to the Target Brain penetration Volume of Distribution and Duration Distribution and Tmax CLEARANCE The Clearance Processes Role of Transport Proteins in Drug Clearance Interplay Between Metabolic and Renal Clearance Role of Lipophilicity in Drug Clearance RENAL CLEARANCE Kidney Anatomy and Function Lipophilicity and Reabsorption by the Kidney Effect of Charge on Renal Clearance Plasma Protein Binding and Renal Clearance Balancing Renal Clearance and Absorption Renal Clearance and Drug Design METABOLIC (HEPATIC) CLEARANCE Function of Metabolism (Biotransformation) Cytochrome P450 Other oxidative processes Oxidative Metablism and Drug Design Non-Specific Esterases Prodrugs to Aid Membrane Transfer Enzymes Catalysing Drug Conjugation Stability to Conjugation Processes Pharmacodynamics and Conjugation TOXICITY Toxicity Findings Importance of dose size Toxicity of selected compound classes Stratification of Toxicity Toxicity Prediction - Computational Toxicology Toxicogenomics Enzyme Induction (CYP3A4) and Drug Design Enzyme Inhibition and Drug Design INTERSPECIES SCALING Objectives of Allometric Scaling Allometric Scaling Species Scaling: Adjusting for Maximum Life-Span Potential Species Scaling: Incorporating Differences in Metabolic Clearance Inter-Species Scaling for Clearance by Hepatic Uptake Elimination Half-Life NEW: Scaling to pharmacological effect NEW: Single animal scaling HIGH(ER) THROUGHPUT ADME STUDIES The HTS Trend Drug Metabolism and Discovery Screening Sequences Physicochemistry Absorption / Permeability Pharmacokinetics NEW: Metabolism and Inhibition NEW: The concept of ADME space Computational Approaches in PK and Metabolism Prediction Outlook